3gfw

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Current revision (07:05, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3gfw' size='340' side='right'caption='[[3gfw]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
<StructureSection load='3gfw' size='340' side='right'caption='[[3gfw]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gfw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GFW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gfw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GFW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PE:2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL'>7PE</scene>, <scene name='pdbligand=S22:1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL'>S22</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPS1L1, TTK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PE:2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL'>7PE</scene>, <scene name='pdbligand=S22:1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL'>S22</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gfw OCA], [https://pdbe.org/3gfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gfw RCSB], [https://www.ebi.ac.uk/pdbsum/3gfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gfw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gfw OCA], [https://pdbe.org/3gfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gfw RCSB], [https://www.ebi.ac.uk/pdbsum/3gfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gfw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dual-specificity kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Choi, H]]
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[[Category: Choi H]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P]]
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[[Category: Grey N]]
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[[Category: Grey, N]]
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[[Category: Keates T]]
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[[Category: Keates, T]]
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[[Category: King O]]
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[[Category: King, O]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Picaud SS]]
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[[Category: Picaud, S S]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W]]
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[[Category: Soundararajan M]]
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[[Category: Structural genomic]]
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[[Category: Weigelt J]]
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[[Category: Soundararajan, M]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J]]
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[[Category: Atp-binding]]
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[[Category: Dual specificity]]
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[[Category: Esk]]
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[[Category: Hmps1]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphotyrosine picked threonine kinase]]
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[[Category: Pyt]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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[[Category: Ttk]]
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[[Category: Tyrosine-protein kinase]]
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Current revision

Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrolo-pyridin ligand

PDB ID 3gfw

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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