3gkl

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Current revision (07:07, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3gkl' size='340' side='right'caption='[[3gkl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3gkl' size='340' side='right'caption='[[3gkl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gkl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GKL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gkl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GKL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gjn|3gjn]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">colE7, cea ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), imm, ceiE9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [https://pdbe.org/3gkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [https://www.ebi.ac.uk/pdbsum/3gkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gkl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [https://pdbe.org/3gkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [https://www.ebi.ac.uk/pdbsum/3gkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gkl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria. [[https://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.
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[https://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dym, O]]
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[[Category: Dym O]]
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[[Category: ISPC, Israel Structural Proteomics Center]]
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[[Category: Tawfik DS]]
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[[Category: Tawfik, D S]]
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[[Category: Antibiotic]]
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[[Category: Antimicrobial]]
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[[Category: Bacteriocin]]
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[[Category: Bacteriocin immunity]]
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[[Category: Endonuclease]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Nuclease]]
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[[Category: Plasmid]]
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[[Category: Protein-protein complex]]
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[[Category: Structural genomic]]
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[[Category: Zinc]]
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Current revision

Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins

PDB ID 3gkl

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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