This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3gw9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:13, 6 September 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3gw9' size='340' side='right'caption='[[3gw9]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
<StructureSection load='3gw9' size='340' side='right'caption='[[3gw9]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3gw9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GW9 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3gw9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GW9 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VNI:N-[(1R)-1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHYL]-4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZAMIDE'>VNI</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3g1q|3g1q]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=VNI:N-[(1R)-1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHYL]-4-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)BENZAMIDE'>VNI</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP51, Tb11.02.4080 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gw9 OCA], [https://pdbe.org/3gw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gw9 RCSB], [https://www.ebi.ac.uk/pdbsum/3gw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gw9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gw9 OCA], [https://pdbe.org/3gw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gw9 RCSB], [https://www.ebi.ac.uk/pdbsum/3gw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gw9 ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q385E8_TRYB2 Q385E8_TRYB2]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 29: Line 29:
</div>
</div>
<div class="pdbe-citations 3gw9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3gw9" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 34: Line 37:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Sterol 14-demethylase]]
+
[[Category: Trypanosoma brucei]]
-
[[Category: Hargrove, T Y]]
+
[[Category: Hargrove TY]]
-
[[Category: Harp, J]]
+
[[Category: Harp J]]
-
[[Category: Lepesheva, G I]]
+
[[Category: Lepesheva GI]]
-
[[Category: Waterman, M R]]
+
[[Category: Waterman MR]]
-
[[Category: Wawrzak, Z]]
+
[[Category: Wawrzak Z]]
-
[[Category: Cyp51]]
+
-
[[Category: Cytochrome p450]]
+
-
[[Category: Endoplasmic reticulum]]
+
-
[[Category: Heme]]
+
-
[[Category: Heme-thiolate protein]]
+
-
[[Category: Iron]]
+
-
[[Category: Lipid]]
+
-
[[Category: Monooxygenase]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Sterol 14alpha-demethylase]]
+
-
[[Category: Sterol biosynthesis]]
+

Current revision

Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei bound to an inhibitor N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxaziazol-2-yl)benzamide

PDB ID 3gw9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3gw9"
Personal tools