3h3j
From Proteopedia
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<StructureSection load='3h3j' size='340' side='right'caption='[[3h3j]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='3h3j' size='340' side='right'caption='[[3h3j]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3h3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3h3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H3J FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h3j OCA], [https://pdbe.org/3h3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h3j RCSB], [https://www.ebi.ac.uk/pdbsum/3h3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h3j ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h3j OCA], [https://pdbe.org/3h3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h3j RCSB], [https://www.ebi.ac.uk/pdbsum/3h3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h3j ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/LDH1_STAAC LDH1_STAAC] Appears to be the primary factor that allows S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells.<ref>PMID:18356528</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: L-lactate dehydrogenase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Staphylococcus aureus subsp. aureus COL]] |
| - | [[Category: Almo | + | [[Category: Almo SC]] |
| - | [[Category: Ho | + | [[Category: Ho M-C]] |
| - | [[Category: Schramm | + | [[Category: Schramm VL]] |
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Current revision
Crystal structure of lactate dehydrogenase mutant (A85R) from staphylococcus aureus complexed with NAD and pyruvate
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