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3hr4

From Proteopedia

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Current revision (07:27, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3hr4' size='340' side='right'caption='[[3hr4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3hr4' size='340' side='right'caption='[[3hr4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hr4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HR4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hr4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HR4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Calmodulin, Inducible Nitric Oxide Synthase, NOS2, NOS2A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hr4 OCA], [https://pdbe.org/3hr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hr4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hr4 OCA], [https://pdbe.org/3hr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hr4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
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[https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Iyanaki, T]]
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[[Category: Iyanaki T]]
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[[Category: Kim, J J.K]]
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[[Category: Kim JJK]]
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[[Category: Misra, I]]
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[[Category: Misra I]]
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[[Category: Xia, C]]
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[[Category: Xia C]]
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[[Category: Calmodulin]]
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[[Category: Calmodulin-binding]]
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[[Category: Fad]]
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[[Category: Fmn]]
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[[Category: Heme]]
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[[Category: Inducible nitric oxide synthase]]
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[[Category: Ino]]
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[[Category: Iron]]
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[[Category: Isopeptide bond]]
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[[Category: Metal-binding]]
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[[Category: Methylation]]
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[[Category: Nadp]]
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[[Category: No]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-metal binding protein complex]]
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[[Category: Phosphoprotein]]
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Current revision

Human iNOS Reductase and Calmodulin Complex

PDB ID 3hr4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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