3i6m

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<StructureSection load='3i6m' size='340' side='right'caption='[[3i6m]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
<StructureSection load='3i6m' size='340' side='right'caption='[[3i6m]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3i6m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I6M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3i6m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I6M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G3X:(4AS,6R,8AS)-3-METHOXY-11-(3-PIPERIDIN-1-YLPROPYL)-5,6,9,10,11,12-HEXAHYDRO-4AH-[1]BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL'>G3X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w4l|1w4l]], [[1w6r|1w6r]], [[1qti|1qti]], [[1w76|1w76]], [[1dx6|1dx6]], [[3i6z|3i6z]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G3X:(4AS,6R,8AS)-3-METHOXY-11-(3-PIPERIDIN-1-YLPROPYL)-5,6,9,10,11,12-HEXAHYDRO-4AH-[1]BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL'>G3X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i6m OCA], [https://pdbe.org/3i6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i6m RCSB], [https://www.ebi.ac.uk/pdbsum/3i6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i6m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i6m OCA], [https://pdbe.org/3i6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i6m RCSB], [https://www.ebi.ac.uk/pdbsum/3i6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i6m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
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[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetylcholinesterase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Torpedo californica]]
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[[Category: Tetronarce californica]]
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[[Category: Bartolucci, C]]
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[[Category: Bartolucci C]]
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[[Category: Lamba, D]]
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[[Category: Lamba D]]
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[[Category: Alternative splicing]]
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[[Category: Alzheimer's disease]]
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[[Category: Bis-functional galanthamine derivative]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Cholinesterase]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Gpi-anchor]]
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[[Category: Hydrolase]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Neurotransmitter degradation]]
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[[Category: Serine esterase]]
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[[Category: Serine hydrolase]]
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[[Category: Synapse]]
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Revision as of 07:39, 6 September 2023

3D Structure of Torpedo californica acetylcholinesterase complexed with N-piperidinopropyl-galanthamine

PDB ID 3i6m

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