This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3imc
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='3imc' size='340' side='right'caption='[[3imc]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='3imc' size='340' side='right'caption='[[3imc]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3imc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3imc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IMC FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BZ3:5-METHOXY-1H-INDOLE'>BZ3</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | ||
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3imc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imc OCA], [https://pdbe.org/3imc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3imc RCSB], [https://www.ebi.ac.uk/pdbsum/3imc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3imc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3imc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3imc OCA], [https://pdbe.org/3imc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3imc RCSB], [https://www.ebi.ac.uk/pdbsum/3imc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3imc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 30: | Line 28: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Pantoate--beta-alanine ligase]] | ||
| - | [[Category: Abell, C]] | ||
| - | [[Category: Blundell, T L]] | ||
| - | [[Category: Ciulli, A]] | ||
| - | [[Category: Hung, A W]] | ||
| - | [[Category: Silvestre, H L]] | ||
| - | [[Category: Wen, S]] | ||
| - | [[Category: Atp-binding]] | ||
| - | [[Category: Drug design]] | ||
| - | [[Category: Enzyme]] | ||
| - | [[Category: Fragment-based]] | ||
| - | [[Category: Ligase]] | ||
| - | [[Category: Magnesium]] | ||
| - | [[Category: Metal-binding]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: | + | [[Category: Abell C]] |
| - | [[Category: | + | [[Category: Blundell TL]] |
| + | [[Category: Ciulli A]] | ||
| + | [[Category: Hung AW]] | ||
| + | [[Category: Silvestre HL]] | ||
| + | [[Category: Wen S]] | ||
Current revision
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.6 Ang resolution in complex with fragment compound 5-methoxyindole, sulfate and glycerol
| |||||||||||
