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3itk

From Proteopedia

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Current revision (07:57, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3itk' size='340' side='right'caption='[[3itk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3itk' size='340' side='right'caption='[[3itk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3itk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ITK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3itk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ITK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ITK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2q3e|2q3e]], [[2qg4|2qg4]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UGDH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3itk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3itk OCA], [https://pdbe.org/3itk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3itk RCSB], [https://www.ebi.ac.uk/pdbsum/3itk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3itk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3itk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3itk OCA], [https://pdbe.org/3itk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3itk RCSB], [https://www.ebi.ac.uk/pdbsum/3itk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3itk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/UGDH_HUMAN UGDH_HUMAN]] Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
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[https://www.uniprot.org/uniprot/UGDH_HUMAN UGDH_HUMAN] Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: UDP-glucose 6-dehydrogenase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Chaikuad A]]
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[[Category: Chaikuad, A]]
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[[Category: Edwards AM]]
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[[Category: Delft, F von]]
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[[Category: Egger S]]
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[[Category: Edwards, A M]]
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[[Category: Filippakopoulos P]]
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[[Category: Egger, S]]
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[[Category: Kavanagh KL]]
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[[Category: Filippakopoulos, P]]
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[[Category: Muniz JRC]]
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[[Category: Kavanagh, K L]]
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[[Category: Nidetzky B]]
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[[Category: Muniz, J R.C]]
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[[Category: Oppermann U]]
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[[Category: Nidetzky, B]]
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[[Category: Sethi R]]
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[[Category: Oppermann, U]]
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[[Category: Weigelt J]]
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[[Category: Structural genomic]]
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[[Category: Yue WW]]
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[[Category: Sethi, R]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J]]
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[[Category: Yue, W W]]
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[[Category: Nad]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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Current revision

Crystal structure of human UDP-glucose dehydrogenase Thr131Ala, apo form.

PDB ID 3itk

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OCA

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