3jsk
From Proteopedia
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<StructureSection load='3jsk' size='340' side='right'caption='[[3jsk]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='3jsk' size='340' side='right'caption='[[3jsk]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3jsk]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3jsk]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSK FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHZ:ADENOSINE+DIPHOSPHATE+5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC+ACID'>AHZ</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [https://pdbe.org/3jsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [https://www.ebi.ac.uk/pdbsum/3jsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [https://pdbe.org/3jsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [https://www.ebi.ac.uk/pdbsum/3jsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/THI4_NEUCR THI4_NEUCR] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.[HAMAP-Rule:MF_03158] | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Chrysonilia crassa]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Neurospora crassa]] |
| - | [[Category: | + | [[Category: Bale S]] |
| - | [[Category: | + | [[Category: Ealick SE]] |
| - | [[Category: | + | [[Category: Kang YN]] |
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Current revision
Thiazole synthase from Neurospora crassa
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