|
|
| Line 1: |
Line 1: |
| | | | |
| | ==Crystal Structure of chicken CD1-1== | | ==Crystal Structure of chicken CD1-1== |
| - | <StructureSection load='3jvg' size='340' side='right' caption='[[3jvg]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='3jvg' size='340' side='right'caption='[[3jvg]], [[Resolution|resolution]] 2.20Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3jvg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JVG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JVG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3jvg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JVG FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3dbx|3dbx]], [[1zt4|1zt4]], [[2fik|2fik]], [[1onq|1onq]], [[1uqs|1uqs]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD1A1, chicken cd1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK]), B2M, beta-2-microglobulin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jvg OCA], [https://pdbe.org/3jvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jvg RCSB], [https://www.ebi.ac.uk/pdbsum/3jvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jvg ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jvg OCA], [http://pdbe.org/3jvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jvg RCSB], [http://www.ebi.ac.uk/pdbsum/3jvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jvg ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/B2MG_CHICK B2MG_CHICK]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | + | [https://www.uniprot.org/uniprot/A5HUM9_CHICK A5HUM9_CHICK] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
| Line 32: |
Line 31: |
| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | + | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Chick]] | + | [[Category: Gallus gallus]] |
| - | [[Category: Dvir, H]] | + | [[Category: Large Structures]] |
| - | [[Category: Wang, J]] | + | [[Category: Dvir H]] |
| - | [[Category: Zajonc, D M]] | + | [[Category: Wang J]] |
| - | [[Category: Antigen]] | + | [[Category: Zajonc DM]] |
| - | [[Category: Cd1]]
| + | |
| - | [[Category: Disulfide bond]]
| + | |
| - | [[Category: Immune response]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Immunoglobulin domain]]
| + | |
| - | [[Category: Lipid]]
| + | |
| - | [[Category: Mhc i]]
| + | |
| - | [[Category: Polymorphism]]
| + | |
| - | [[Category: Secreted]]
| + | |
| - | [[Category: T-cell]]
| + | |
| - | [[Category: Transmembrane]]
| + | |
| Structural highlights
Function
A5HUM9_CHICK
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
CD1 proteins present self- and foreign lipid Ags to activate specific T cells in the mammalian immune system. These T cells play an important role in controlling autoimmune diseases, suppression of tumor growth, and host defense against invading pathogens. Humans use five CD1 isoforms, whereas only two exist in birds. Unlike mammals' CD1, the structure of chicken CD1-2 showed a primitive lipid-binding groove, suggesting that chicken may only recognize single-chain lipids. In contrast, the crystal structure of the second chicken CD1 isoform, chCD1-1, reported in this study at 2.2 A resolution, reveals an elaborated binding groove with a dual-pocket, dual-cleft architecture. The A' and F' deep pockets are separated from each other, but each is connected to a hydrophobic surface cleft, which may participate in lipid binding. The long endogenous ligand found inside the binding groove of chCD1-1, together with binding data on various glycolipids and mycolic acid, strongly suggest that the unique avian CD1 family could bind long dual- and possibly triacyl-chain lipids.
Structural basis for lipid-antigen recognition in avian immunity.,Dvir H, Wang J, Ly N, Dascher CC, Zajonc DM J Immunol. 2010 Mar 1;184(5):2504-11. Epub 2010 Jan 25. PMID:20100930[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Dvir H, Wang J, Ly N, Dascher CC, Zajonc DM. Structural basis for lipid-antigen recognition in avian immunity. J Immunol. 2010 Mar 1;184(5):2504-11. Epub 2010 Jan 25. PMID:20100930 doi:10.4049/jimmunol.0903509
|
