3jzb

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==Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC==
==Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC==
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<StructureSection load='3jzb' size='340' side='right' caption='[[3jzb]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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<StructureSection load='3jzb' size='340' side='right'caption='[[3jzb]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3jzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3jzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC+ACID'>4HY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.007&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC+ACID'>4HY</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jzc|3jzc]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzb OCA], [https://pdbe.org/3jzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jzb RCSB], [https://www.ebi.ac.uk/pdbsum/3jzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzb ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THRA, hCG_1749555 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzb OCA], [http://pdbe.org/3jzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzb RCSB], [http://www.ebi.ac.uk/pdbsum/3jzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzb ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[https://omim.org/entry/614450 614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Nuclear hormone receptor. High affinity receptor for triiodothyronine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Aparicio, R]]
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[[Category: Large Structures]]
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[[Category: Dias, S M.G]]
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[[Category: Aparicio R]]
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[[Category: Nascimento, A S]]
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[[Category: Dias SMG]]
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[[Category: Nunes, F M]]
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[[Category: Nascimento AS]]
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[[Category: Dna-binding]]
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[[Category: Nunes FM]]
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[[Category: Entropy]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Receptor]]
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[[Category: Thyroid]]
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[[Category: Tr]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Triac]]
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[[Category: Zinc-finger]]
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Revision as of 08:06, 6 September 2023

Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC

PDB ID 3jzb

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