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3jzi

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Current revision (08:06, 6 September 2023) (edit) (undo)
 
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==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series==
==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series==
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<StructureSection load='3jzi' size='340' side='right' caption='[[3jzi]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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<StructureSection load='3jzi' size='340' side='right'caption='[[3jzi]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jzf|3jzf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">accC, fabG, b3256, JW3224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [https://pdbe.org/3jzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [https://www.ebi.ac.uk/pdbsum/3jzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzi ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [http://pdbe.org/3jzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [http://www.ebi.ac.uk/pdbsum/3jzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzi ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACCC_ECOLI ACCC_ECOLI]] This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
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[https://www.uniprot.org/uniprot/ACCC_ECOLI ACCC_ECOLI] This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Acetyl-CoA carboxylase|Acetyl-CoA carboxylase]]
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*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Black, T]]
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[[Category: Large Structures]]
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[[Category: Cheng, C]]
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[[Category: Black T]]
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[[Category: Kawahata, N]]
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[[Category: Cheng C]]
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[[Category: Mann, P]]
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[[Category: Kawahata N]]
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[[Category: Orth, P]]
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[[Category: Mann P]]
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[[Category: Shipps, G W]]
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[[Category: Orth P]]
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[[Category: Soriano, A]]
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[[Category: Shipps GW]]
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[[Category: Soucy, K]]
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[[Category: Soriano A]]
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[[Category: Sun, B]]
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[[Category: Soucy K]]
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[[Category: Xiao, L]]
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[[Category: Sun B]]
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[[Category: Yang, Z]]
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[[Category: Xiao L]]
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[[Category: Accase]]
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[[Category: Yang Z]]
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[[Category: Accc]]
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[[Category: Acetyl coenzyme-a carboxylase]]
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[[Category: Atp-binding]]
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[[Category: Biotin]]
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[[Category: Biotin carboxylase]]
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[[Category: Fatty acid biosynthesis]]
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[[Category: Ligase]]
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[[Category: Lipid synthesis]]
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[[Category: Nucleotide-binding]]
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Current revision

Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series

PDB ID 3jzi

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