1mpv
From Proteopedia
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[[Image:1mpv.gif|left|200px]] | [[Image:1mpv.gif|left|200px]] | ||
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'''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide''' | '''Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MPV is a [[Single protein]] structure | + | 1MPV is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Yan, M.]] | [[Category: Yan, M.]] | ||
[[Category: Yin, J.]] | [[Category: Yin, J.]] | ||
| - | [[Category: | + | [[Category: Beta-hairpin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:19 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 22:34, 2 May 2008
Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide
Overview
The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF.
About this Structure
1MPV is a Single protein structure. Full crystallographic information is available from OCA.
Reference
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2., Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM, Immunity. 2002 Oct;17(4):515-24. PMID:12387744 Page seeded by OCA on Sat May 3 01:34:19 2008
