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3kbc

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Current revision (08:13, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3kbc' size='340' side='right'caption='[[3kbc]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
<StructureSection load='3kbc' size='340' side='right'caption='[[3kbc]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kbc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KBC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kbc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KBC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.51&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nwl|2nwl]], [[2nww|2nww]], [[2nwx|2nwx]], [[1xfh|1xfh]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH1295 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbc OCA], [https://pdbe.org/3kbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kbc RCSB], [https://www.ebi.ac.uk/pdbsum/3kbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kbc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbc OCA], [https://pdbe.org/3kbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kbc RCSB], [https://www.ebi.ac.uk/pdbsum/3kbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kbc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLT_PYRHO GLT_PYRHO] Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).<ref>PMID:17230192</ref> <ref>PMID:17435767</ref> <ref>PMID:19380583</ref> [PDB:4P19]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pyrococcus shinkaii]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Boudker, O]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: Ginter, C]]
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[[Category: Boudker O]]
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[[Category: Reyes, N]]
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[[Category: Ginter C]]
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[[Category: Amino acid transporter]]
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[[Category: Reyes N]]
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[[Category: Aspartate transporter]]
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[[Category: Cysteine cross-link]]
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[[Category: Inward-facing]]
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[[Category: Transmembrane transporter]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of GltPh K55C-A364C mutant crosslinked with divalent mercury

PDB ID 3kbc

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