3kci

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:13, 6 September 2023) (edit) (undo)
 
Line 1: Line 1:
==The third RLD domain of HERC2==
==The third RLD domain of HERC2==
-
<StructureSection load='3kci' size='340' side='right' caption='[[3kci]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+
<StructureSection load='3kci' size='340' side='right'caption='[[3kci]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3kci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KCI FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3kci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KCI FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">D15F37S1, DKFZP547P028, HERC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kci OCA], [http://pdbe.org/3kci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kci RCSB], [http://www.ebi.ac.uk/pdbsum/3kci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kci ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kci OCA], [https://pdbe.org/3kci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kci RCSB], [https://www.ebi.ac.uk/pdbsum/3kci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kci ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN]] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>
+
[https://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 23: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Large Structures]]
-
[[Category: Bochkarev, A]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C]]
+
[[Category: Bochkarev A]]
-
[[Category: Dhe-Paganon, S]]
+
[[Category: Bountra C]]
-
[[Category: Edwards, A M]]
+
[[Category: Dhe-Paganon S]]
-
[[Category: Qiu, L]]
+
[[Category: Edwards AM]]
-
[[Category: Vesterberg, A]]
+
[[Category: Qiu L]]
-
[[Category: Walker, J R]]
+
[[Category: Vesterberg A]]
-
[[Category: Weigelt, J]]
+
[[Category: Walker JR]]
-
[[Category: Coiled coil]]
+
[[Category: Weigelt J]]
-
[[Category: Ligase]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Rcc1]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Ubl conjugation pathway]]
+
-
[[Category: Wd repeat]]
+
-
[[Category: Wd40]]
+
-
[[Category: Zinc]]
+
-
[[Category: Zinc-finger]]
+

Current revision

The third RLD domain of HERC2

PDB ID 3kci

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3kci"
Personal tools