1mpx

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[[Image:1mpx.gif|left|200px]]
[[Image:1mpx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mpx |SIZE=350|CAPTION= <scene name='initialview01'>1mpx</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1mpx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amino-acid_esterase Alpha-amino-acid esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.43 3.1.1.43] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1mpx| PDB=1mpx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpx OCA], [http://www.ebi.ac.uk/pdbsum/1mpx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mpx RCSB]</span>
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}}
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'''ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE'''
'''ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE'''
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[[Category: Polderman-Tijmes, J J.]]
[[Category: Polderman-Tijmes, J J.]]
[[Category: Vries, E J.de.]]
[[Category: Vries, E J.de.]]
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[[Category: alpha/beta hydrolase]]
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[[Category: Alpha/beta hydrolase]]
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[[Category: jellyroll]]
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[[Category: Jellyroll]]
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[[Category: selenomethionine]]
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[[Category: Selenomethionine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:19:27 2008''
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Revision as of 22:34, 2 May 2008

Image:1mpx.gif

Template:STRUCTURE 1mpx

ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE


Overview

alpha-Amino acid ester hydrolases (AEHs) catalyze the hydrolysis and synthesis of esters and amides with an alpha-amino group. As such, they can synthesize beta-lactam antibiotics from acyl compounds and beta-lactam nuclei obtained from the hydrolysis of natural antibiotics. This article describes the gene sequence and the 1.9-A resolution crystal structure of the AEH from Xanthomonas citri. The enzyme consists of an alpha/beta-hydrolase fold domain, a helical cap domain, and a jellyroll beta-domain. Structural homology was observed to the Rhodococcus cocaine esterase, indicating that both enzymes belong to the same class of bacterial hydrolases. Docking of a beta-lactam antibiotic in the active site explains the substrate specificity, specifically the necessity of an alpha-amino group on the substrate, and explains the low specificity toward the beta-lactam nucleus.

About this Structure

1MPX is a Single protein structure of sequence from Xanthomonas citri. Full crystallographic information is available from OCA.

Reference

The sequence and crystal structure of the alpha-amino acid ester hydrolase from Xanthomonas citri define a new family of beta-lactam antibiotic acylases., Barends TR, Polderman-Tijmes JJ, Jekel PA, Hensgens CM, de Vries EJ, Janssen DB, Dijkstra BW, J Biol Chem. 2003 Jun 20;278(25):23076-84. Epub 2003 Apr 8. PMID:12684501 Page seeded by OCA on Sat May 3 01:34:37 2008

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