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1mq0

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[[Image:1mq0.gif|left|200px]]
[[Image:1mq0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mq0 |SIZE=350|CAPTION= <scene name='initialview01'>1mq0</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1mq0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BRD:1-BETA-RIBOFURANOSYL-1,3-DIAZEPINONE'>BRD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1mq0| PDB=1mq0 | SCENE= }}
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|RELATEDENTRY=[[1jtk|1JTK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mq0 OCA], [http://www.ebi.ac.uk/pdbsum/1mq0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mq0 RCSB]</span>
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}}
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'''Crystal Structure of Human Cytidine Deaminase'''
'''Crystal Structure of Human Cytidine Deaminase'''
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[[Category: Fromme, J C.]]
[[Category: Fromme, J C.]]
[[Category: Verdine, G L.]]
[[Category: Verdine, G L.]]
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[[Category: amine hydrolase]]
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[[Category: Amine hydrolase]]
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[[Category: anticancer]]
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[[Category: Anticancer]]
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[[Category: chemotherapy]]
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[[Category: Chemotherapy]]
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[[Category: cytidine deaminase]]
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[[Category: Cytidine deaminase]]
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[[Category: diazepinone]]
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[[Category: Diazepinone]]
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[[Category: drug]]
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[[Category: Drug]]
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[[Category: edge-to-face interaction]]
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[[Category: Edge-to-face interaction]]
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[[Category: enzyme]]
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[[Category: Enzyme]]
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[[Category: human]]
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[[Category: Human]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: leukemia]]
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[[Category: Leukemia]]
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[[Category: phi-phi interaction]]
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[[Category: Phi-phi interaction]]
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[[Category: protein]]
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[[Category: Protein]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:19:31 2008''
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Revision as of 22:34, 2 May 2008

Image:1mq0.gif

Template:STRUCTURE 1mq0

Crystal Structure of Human Cytidine Deaminase


Overview

Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137.

About this Structure

1MQ0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:15689149 Page seeded by OCA on Sat May 3 01:34:40 2008

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OCA

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