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| | ==Structure of Triosephosphate Isomerase from Cryptosporidium Parvum at 1.55A Resolution== | | ==Structure of Triosephosphate Isomerase from Cryptosporidium Parvum at 1.55A Resolution== |
| - | <StructureSection load='3krs' size='340' side='right' caption='[[3krs]], [[Resolution|resolution]] 1.55Å' scene=''> | + | <StructureSection load='3krs' size='340' side='right'caption='[[3krs]], [[Resolution|resolution]] 1.55Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3krs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Crypi Crypi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KRS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3krs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_parvum_Iowa_II Cryptosporidium parvum Iowa II]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KRS FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cgd1_3040 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353152 CRYPI])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3krs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3krs OCA], [https://pdbe.org/3krs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3krs RCSB], [https://www.ebi.ac.uk/pdbsum/3krs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3krs ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3krs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3krs OCA], [http://pdbe.org/3krs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3krs RCSB], [http://www.ebi.ac.uk/pdbsum/3krs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3krs ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q5CSE7_CRYPI Q5CSE7_CRYPI] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Crypi]]
| + | [[Category: Cryptosporidium parvum Iowa II]] |
| - | [[Category: Triose-phosphate isomerase]]
| + | [[Category: Large Structures]] |
| - | [[Category: Structural genomic]]
| + | |
| - | [[Category: Cryptosporidium parvum]] | + | |
| - | [[Category: Emerald biostructure]] | + | |
| - | [[Category: Isomerase]]
| + | |
| - | [[Category: Niaid]]
| + | |
| - | [[Category: Nih]]
| + | |
| - | [[Category: Sbri]]
| + | |
| - | [[Category: Ssgcid]]
| + | |
| - | [[Category: Triosephosphate isomerase]]
| + | |
| - | [[Category: University of washington]]
| + | |
| Structural highlights
Function
Q5CSE7_CRYPI
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Cryptosporidium parvum is one of several Cryptosporidium spp. that cause the parasitic infection cryptosporidiosis. Cryptosporidiosis is a diarrheal infection that is spread via the fecal-oral route and is commonly caused by contaminated drinking water. Triosephosphate isomerase is an enzyme that is ubiquitous to all organisms that perform glycolysis. Triosephosphate isomerase catalyzes the formation of glyceraldehyde 3-phosphate from dihydroxyacetone phosphate, which is a critical step to ensure the maximum ATP production per glucose molecule. In this paper, the 1.55 A resolution crystal structure of the open-loop form of triosephosphate isomerase from C. parvum Iowa II is presented. An unidentified electron density was found in the active site.
Structure of triosephosphate isomerase from Cryptosporidium parvum.,Nguyen TN, Abendroth J, Leibly DJ, Le KP, Guo W, Kelley A, Stewart L, Myler PJ, Van Voorhis WC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1095-9. Epub 2011 Aug 16. PMID:21904056[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Nguyen TN, Abendroth J, Leibly DJ, Le KP, Guo W, Kelley A, Stewart L, Myler PJ, Van Voorhis WC. Structure of triosephosphate isomerase from Cryptosporidium parvum. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1095-9. Epub 2011 Aug 16. PMID:21904056 doi:10.1107/S1744309111019178
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