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3ks8

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Current revision (08:22, 6 September 2023) (edit) (undo)
 
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==Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA==
==Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA==
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<StructureSection load='3ks8' size='340' side='right' caption='[[3ks8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3ks8' size='340' side='right'caption='[[3ks8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ks8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebore Ebore]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KS8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ks8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KS8 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ks4|3ks4]], [[3fke|3fke]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.401&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">REBOVgp2, VP35 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=129003 EBORE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ks8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ks8 OCA], [https://pdbe.org/3ks8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ks8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ks8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ks8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ks8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ks8 OCA], [http://pdbe.org/3ks8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ks8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ks8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ks8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
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[https://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/3ks8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/3ks8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ebore]]
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[[Category: Large Structures]]
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[[Category: Bornholdt, Z A]]
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[[Category: Reston ebolavirus - Reston]]
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[[Category: Kimberlin, C R]]
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[[Category: Bornholdt ZA]]
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[[Category: Li, S]]
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[[Category: Kimberlin CR]]
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[[Category: Macrae, I J]]
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[[Category: Li S]]
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[[Category: Saphire, E O]]
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[[Category: Macrae IJ]]
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[[Category: Woods, V L]]
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[[Category: Saphire EO]]
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[[Category: Ebolavirus]]
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[[Category: Woods VL]]
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[[Category: Host cytoplasm]]
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[[Category: Interferon]]
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[[Category: Interferon antiviral system evasion]]
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[[Category: Protein-rna complex]]
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[[Category: Reston]]
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[[Category: Rna replication]]
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[[Category: Rna-binding]]
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[[Category: Rna-binding protein]]
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[[Category: Transcription]]
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[[Category: Viral protein-rna complex]]
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[[Category: Virion]]
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Current revision

Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA

PDB ID 3ks8

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