3lq3

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Current revision (08:42, 6 September 2023) (edit) (undo)
 
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==Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide==
==Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide==
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<StructureSection load='3lq3' size='340' side='right' caption='[[3lq3]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
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<StructureSection load='3lq3' size='340' side='right'caption='[[3lq3]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lq3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LQ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lq3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LQ3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=HC7:(2S)-2-[4-({DIMETHYL[2-(PHOSPHONOOXY)ETHYL]AMMONIO}ACETYL)BIPHENYL-4-YL]-2-HYDROXY-4,4-DIMETHYLMORPHOLIN-4-IUM'>HC7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHKB, CHETK, CHKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=HC7:(2S)-2-[4-({DIMETHYL[2-(PHOSPHONOOXY)ETHYL]AMMONIO}ACETYL)BIPHENYL-4-YL]-2-HYDROXY-4,4-DIMETHYLMORPHOLIN-4-IUM'>HC7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lq3 OCA], [http://pdbe.org/3lq3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lq3 RCSB], [http://www.ebi.ac.uk/pdbsum/3lq3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lq3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lq3 OCA], [https://pdbe.org/3lq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lq3 RCSB], [https://www.ebi.ac.uk/pdbsum/3lq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lq3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CHKB_HUMAN CHKB_HUMAN]] Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.<ref>PMID:19915674</ref>
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[https://www.uniprot.org/uniprot/CHKB_HUMAN CHKB_HUMAN] Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.<ref>PMID:19915674</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/3lq3_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/3lq3_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3lq3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3lq3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Choline kinase 3D structures|Choline kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: Hong, B S]]
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[[Category: Edwards AM]]
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[[Category: MacKenzie, F]]
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[[Category: Hong BS]]
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[[Category: Park, H W]]
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[[Category: MacKenzie F]]
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[[Category: Rabeh, W M]]
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[[Category: Park HW]]
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[[Category: Structural genomic]]
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[[Category: Rabeh WM]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Atp-binding]]
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[[Category: Choline kinase]]
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[[Category: Hemicholinium-3]]
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[[Category: Kinase]]
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[[Category: Non-protein kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phospholipid biosynthesis]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphorylation]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

PDB ID 3lq3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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