3lxy

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Current revision (08:45, 6 September 2023) (edit) (undo)
 
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==Crystal structure of 4-hydroxythreonine-4-phosphate dehydrogenase from Yersinia pestis CO92==
==Crystal structure of 4-hydroxythreonine-4-phosphate dehydrogenase from Yersinia pestis CO92==
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<StructureSection load='3lxy' size='340' side='right' caption='[[3lxy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3lxy' size='340' side='right'caption='[[3lxy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lxy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LXY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lxy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LXY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pdxA, YPO0493, y3682, YP_3686 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxythreonine-4-phosphate_dehydrogenase 4-hydroxythreonine-4-phosphate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.262 1.1.1.262] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lxy OCA], [https://pdbe.org/3lxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lxy RCSB], [https://www.ebi.ac.uk/pdbsum/3lxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lxy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lxy OCA], [http://pdbe.org/3lxy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lxy RCSB], [http://www.ebi.ac.uk/pdbsum/3lxy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lxy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDXA_YERPE PDXA_YERPE]] Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity).
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[https://www.uniprot.org/uniprot/PDXA_YERPE PDXA_YERPE] Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 4-hydroxythreonine-4-phosphate dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Anderson, W]]
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[[Category: Yersinia pestis]]
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[[Category: Anderson W]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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[[Category: Joachimiak, A]]
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[[Category: Joachimiak A]]
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[[Category: Kwon, K]]
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[[Category: Kwon K]]
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[[Category: Maltseva, N]]
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[[Category: Maltseva N]]
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[[Category: Nocek, B]]
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[[Category: Nocek B]]
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[[Category: Csgid]]
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[[Category: Dehydrogenase]]
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[[Category: Metal-binding]]
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[[Category: Nad]]
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[[Category: Nad-dependent]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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[[Category: Pdxa]]
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[[Category: Pyridoxine biosynthesis]]
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Current revision

Crystal structure of 4-hydroxythreonine-4-phosphate dehydrogenase from Yersinia pestis CO92

PDB ID 3lxy

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