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3m18

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Current revision (08:47, 6 September 2023) (edit) (undo)
 
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==Crystal structure of variable lymphocyte receptor VLRA.R2.1 in complex with hen egg lysozyme==
==Crystal structure of variable lymphocyte receptor VLRA.R2.1 in complex with hen egg lysozyme==
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<StructureSection load='3m18' size='340' side='right' caption='[[3m18]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='3m18' size='340' side='right'caption='[[3m18]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3m18]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Petma Petma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M18 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3m18]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M18 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m19|3m19]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VLRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7757 PETMA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m18 OCA], [https://pdbe.org/3m18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m18 RCSB], [https://www.ebi.ac.uk/pdbsum/3m18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m18 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m18 OCA], [http://pdbe.org/3m18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m18 RCSB], [http://www.ebi.ac.uk/pdbsum/3m18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m18 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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[https://www.uniprot.org/uniprot/C7B6Y3_PETMA C7B6Y3_PETMA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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*[[Lamprey Variable Lymphocyte Receptor|Lamprey Variable Lymphocyte Receptor]]
*[[Lamprey Variable Lymphocyte Receptor|Lamprey Variable Lymphocyte Receptor]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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*[[Variable lymphocyte receptor|Variable lymphocyte receptor]]
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Petma]]
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[[Category: Petromyzon marinus]]
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[[Category: Deng, L]]
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[[Category: Deng L]]
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[[Category: Mariuzza, R A]]
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[[Category: Mariuzza RA]]
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[[Category: Velikovsky, C A]]
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[[Category: Velikovsky CA]]
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[[Category: Adaptive immunity]]
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[[Category: Antibody]]
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[[Category: B cell]]
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[[Category: Immune system]]
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[[Category: Leucine-rich repeat]]
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[[Category: T cell]]
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[[Category: Variable lymphocyte receptor]]
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Current revision

Crystal structure of variable lymphocyte receptor VLRA.R2.1 in complex with hen egg lysozyme

PDB ID 3m18

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