3m8v
From Proteopedia
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<StructureSection load='3m8v' size='340' side='right'caption='[[3m8v]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='3m8v' size='340' side='right'caption='[[3m8v]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3m8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3m8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M8V FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8v OCA], [https://pdbe.org/3m8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m8v RCSB], [https://www.ebi.ac.uk/pdbsum/3m8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8v ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8v OCA], [https://pdbe.org/3m8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m8v RCSB], [https://www.ebi.ac.uk/pdbsum/3m8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Nielsen | + | [[Category: Nielsen TK]] |
| - | [[Category: Prive | + | [[Category: Prive GG]] |
| - | [[Category: Stogios | + | [[Category: Stogios PJ]] |
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Current revision
Crystal structure of the BTB domain from Kaiso/ZBTB33, form II
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