1mr1

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[[Image:1mr1.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mr1 OCA], [http://www.ebi.ac.uk/pdbsum/1mr1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mr1 RCSB]</span>
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'''Crystal Structure of a Smad4-Ski Complex'''
'''Crystal Structure of a Smad4-Ski Complex'''
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[[Category: Wu, J W.]]
[[Category: Wu, J W.]]
[[Category: Zhang, F.]]
[[Category: Zhang, F.]]
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[[Category: cancer]]
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[[Category: Cancer]]
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[[Category: protein interaction]]
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[[Category: Protein interaction]]
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[[Category: ski]]
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[[Category: Ski]]
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[[Category: smad]]
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[[Category: Smad]]
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[[Category: tgf-b signaling]]
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[[Category: Tgf-b signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:37:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:19:55 2008''
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Revision as of 22:37, 2 May 2008

Image:1mr1.gif

Template:STRUCTURE 1mr1

Crystal Structure of a Smad4-Ski Complex


Overview

The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with that required for binding of the R-Smads. Indeed, Ski disrupts the formation of a functional complex between the Co- and R-Smads, explaining how it could lead to repression of TGF-beta, activin, and BMP responses. Intriguingly, the structure of the Ski fragment, stabilized by a bound zinc atom, resembles the SAND domain, in which the corresponding I loop is responsible for DNA binding.

About this Structure

1MR1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling., Wu JW, Krawitz AR, Chai J, Li W, Zhang F, Luo K, Shi Y, Cell. 2002 Nov 1;111(3):357-67. PMID:12419246 Page seeded by OCA on Sat May 3 01:37:04 2008

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