3mp7

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Current revision (08:58, 6 September 2023) (edit) (undo)
 
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==Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes==
==Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes==
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<StructureSection load='3mp7' size='340' side='right' caption='[[3mp7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='3mp7' size='340' side='right'caption='[[3mp7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mp7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MP7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mp7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MP7 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rh5|1rh5]], [[2yxq|2yxq]], [[2yxr|2yxr]], [[2zjs|2zjs]], [[3dkn|3dkn]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">secY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587]), secE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mp7 OCA], [https://pdbe.org/3mp7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mp7 RCSB], [https://www.ebi.ac.uk/pdbsum/3mp7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mp7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mp7 OCA], [http://pdbe.org/3mp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mp7 RCSB], [http://www.ebi.ac.uk/pdbsum/3mp7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mp7 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SECY_PYRFU SECY_PYRFU]] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. Complements an E.coli temperature-sensitive secY mutation; deletion of the last 15 residues prevents complementation, which may indicate a role of this region in translocation.[HAMAP-Rule:MF_01465] [[http://www.uniprot.org/uniprot/SECE_PYRFU SECE_PYRFU]] Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.[HAMAP-Rule:MF_00422]
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[https://www.uniprot.org/uniprot/SECY_PYRFU SECY_PYRFU] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. Complements an E.coli temperature-sensitive secY mutation; deletion of the last 15 residues prevents complementation, which may indicate a role of this region in translocation.[HAMAP-Rule:MF_01465]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mp7_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mp7_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3mp7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3mp7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Preprotein translocase|Preprotein translocase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 43587]]
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[[Category: Large Structures]]
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[[Category: CSMP, Center for Structures of Membrane Proteins]]
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[[Category: Pyrococcus furiosus]]
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[[Category: Egea, P F]]
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[[Category: Egea PF]]
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[[Category: Stroud, R M]]
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[[Category: Stroud RM]]
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[[Category: Center for structures of membrane protein]]
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[[Category: Csmp]]
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[[Category: Membrane insertion]]
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[[Category: Membrane protein complex]]
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[[Category: Preprotein translocase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Protein transport]]
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[[Category: Structural genomic]]
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Current revision

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

PDB ID 3mp7

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OCA

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