3mwt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:02, 6 September 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3mwt' size='340' side='right'caption='[[3mwt]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
<StructureSection load='3mwt' size='340' side='right'caption='[[3mwt]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3mwt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassj Lassj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MWT FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3mwt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MWT FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.982&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3mwp|3mwp]], [[3mx2|3mx2]], [[3mx5|3mx5]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">N, nucleoprotein ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11622 LASSJ])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwt OCA], [https://pdbe.org/3mwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mwt RCSB], [https://www.ebi.ac.uk/pdbsum/3mwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mwt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwt OCA], [https://pdbe.org/3mwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mwt RCSB], [https://www.ebi.ac.uk/pdbsum/3mwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mwt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
+
[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 28: Line 27:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Lassj]]
+
[[Category: Lassa virus Josiah]]
-
[[Category: Dong, C]]
+
[[Category: Dong C]]
-
[[Category: Dong, H]]
+
[[Category: Dong H]]
-
[[Category: Lan, S]]
+
[[Category: Lan S]]
-
[[Category: Liang, Y]]
+
[[Category: Liang Y]]
-
[[Category: Ly, H]]
+
[[Category: Ly H]]
-
[[Category: Qi, X]]
+
[[Category: Qi X]]
-
[[Category: SSPF, Scottish Structural Proteomics Facility]]
+
[[Category: Schelde LM]]
-
[[Category: Schelde, L M]]
+
[[Category: Wallat G]]
-
[[Category: Wallat, G]]
+
[[Category: Wang W]]
-
[[Category: Wang, W]]
+
-
[[Category: Lassa fever virus]]
+
-
[[Category: Nuclear protein]]
+
-
[[Category: Nucleoprotein]]
+
-
[[Category: Scottish structural proteomics facility]]
+
-
[[Category: Sspf]]
+
-
[[Category: Structural genomic]]
+

Current revision

Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+

PDB ID 3mwt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3mwt"
Personal tools