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1n11

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(New page: 200px<br /> <applet load="1n11" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n11, resolution 2.70&Aring;" /> '''D34 REGION OF HUMAN...)
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Revision as of 16:10, 12 November 2007

Image:1n11.gif

1n11, resolution 2.70Å

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D34 REGION OF HUMAN ANKYRIN-R AND LINKER

Contents

Overview

Ankyrins are multifunctional adaptors that link specific proteins to the, membrane-associated, spectrin- actin cytoskeleton. The N-terminal, 'membrane-binding' domain of ankyrins contains 24 ANK repeats and mediates, most binding activities. Repeats 13-24 are especially active, with known, sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell, adhesion molecules. Here we report the crystal structure of a human, ankyrinR construct containing ANK repeats 13-24 and a portion of the, spectrin-binding domain. The ANK repeats are observed to form a contiguous, spiral stack with which the spectrin-binding domain fragment associates as, an extended strand. The structural information has been used to construct, models of all 24 repeats of the membrane-binding domain as well as the, interactions of the repeats with the Cl/HCO(3) anion exchanger and, clathrin. These models, together with available binding studies, suggest, that ion transporters such as the anion exchanger associate in a large, central cavity formed by the ANK repeat spiral, while clathrin and cell, adhesion molecules associate with specific regions outside this cavity.

Disease

Known diseases associated with this structure: Chondrocalcinosis 2 OMIM:[605145], Craniometaphyseal dysplasia OMIM:[605145]

About this Structure

1N11 is a Single protein structure of sequence from Homo sapiens with BR and CL as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of a 12 ANK repeat stack from human ankyrinR., Michaely P, Tomchick DR, Machius M, Anderson RG, EMBO J. 2002 Dec 2;21(23):6387-96. PMID:12456646

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