3nk2

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Current revision (09:16, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3nk2' size='340' side='right'caption='[[3nk2]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='3nk2' size='340' side='right'caption='[[3nk2]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Artni Artni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NK2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nk2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenarthrobacter_nicotinovorans Paenarthrobacter nicotinovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NK2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GP7:(1R)-2-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTADECANOYLOXY)METHYL]ETHYL+(12E)-HEXADECA-9,12-DIENOATE'>GP7</scene>, <scene name='pdbligand=LDP:L-DOPAMINE'>LDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ngc|3ngc]], [[3nh3|3nh3]], [[3nho|3nho]], [[3nk0|3nk0]], [[3nk1|3nk1]], [[3nn0|3nn0]], [[3nn6|3nn6]], [[3k7m|3k7m]], [[3k7q|3k7q]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GP7:(1R)-2-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTADECANOYLOXY)METHYL]ETHYL+(12E)-HEXADECA-9,12-DIENOATE'>GP7</scene>, <scene name='pdbligand=LDP:L-DOPAMINE'>LDP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">6-HLNO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29320 ARTNI])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(S)-6-hydroxynicotine_oxidase (S)-6-hydroxynicotine oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.3.5 1.5.3.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nk2 OCA], [https://pdbe.org/3nk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nk2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nk2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nk2 OCA], [https://pdbe.org/3nk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nk2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nk2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HLNO_PAENI HLNO_PAENI] Involved in the degradation of L-nicotine (PubMed:5849820). Catalyzes the oxidation of (S)-6-hydroxynicotine (6-hydroxy-L-nicotine) to 6-hydroxypseudooxynicotine (PubMed:5849820, PubMed:4965794, PubMed:5646150, PubMed:21383134, PubMed:26744768, PubMed:28080034). Oxidation of the pyrrolidine ring of (S)-6-hydroxynicotine leads to the formation of the optically inactive 6-hydroxy-N-methylmyosmine, which hydrolyzes spontaneously to 6-hydroxypseudooxynicotine (PubMed:4965794, PubMed:21383134, PubMed:26744768, PubMed:28080034). Acts with absolute stereospecificity on the L-form of 6-hydroxynicotine (PubMed:4965794). Can also use (S)-6-hydroxynornicotine (PubMed:26744768, PubMed:28080034).<ref>PMID:21383134</ref> <ref>PMID:26744768</ref> <ref>PMID:28080034</ref> <ref>PMID:4965794</ref> <ref>PMID:5646150</ref> <ref>PMID:5849820</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Artni]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bartunik, H D]]
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[[Category: Paenarthrobacter nicotinovorans]]
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[[Category: Kachalova, G S]]
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[[Category: Bartunik HD]]
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[[Category: Enanthiomeric substrate-inhibitor]]
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[[Category: Kachalova GS]]
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[[Category: Flavoenzyme]]
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[[Category: Nicotine degradation]]
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[[Category: Oxidoreductase]]
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Current revision

Complex of 6-hydroxy-L-nicotine oxidase with dopamine

PDB ID 3nk2

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