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3nt7

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Current revision (09:20, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3nt7' size='340' side='right'caption='[[3nt7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3nt7' size='340' side='right'caption='[[3nt7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nt7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_western_reserve Vaccinia virus western reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NT7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nt7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Western_Reserve Vaccinia virus Western Reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NT7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2owq|2owq]], [[2owr|2owr]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">D4R, VACWR109 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=696871 Vaccinia virus Western Reserve])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nt7 OCA], [https://pdbe.org/3nt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nt7 RCSB], [https://www.ebi.ac.uk/pdbsum/3nt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nt7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nt7 OCA], [https://pdbe.org/3nt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nt7 RCSB], [https://www.ebi.ac.uk/pdbsum/3nt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nt7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/UNG_VACCA UNG_VACCA]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA.
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[https://www.uniprot.org/uniprot/UNG_VACCW UNG_VACCW] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Uracil-DNA glycosylase]]
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[[Category: Vaccinia virus Western Reserve]]
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[[Category: Vaccinia virus western reserve]]
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[[Category: Chattopadhyay D]]
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[[Category: Chattopadhyay, D]]
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[[Category: Hydrolase]]
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[[Category: Uracil-dna glycosylase fold]]
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Current revision

Crystal Structure of Vaccinia Virus Uracil DNA Glycosylase R187V Mutant

PDB ID 3nt7

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