1mro

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[[Image:1mro.gif|left|200px]]
[[Image:1mro.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mro |SIZE=350|CAPTION= <scene name='initialview01'>1mro</scene>, resolution 1.16&Aring;
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The line below this paragraph, containing "STRUCTURE_1mro", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=F43:Active+Site'>F43</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AGM:4-METHYL-ARGININE'>AGM</scene>, <scene name='pdbligand=COM:1-THIOETHANESULFONIC+ACID'>COM</scene>, <scene name='pdbligand=F43:FACTOR+430'>F43</scene>, <scene name='pdbligand=GL3:THIOGLYCIN'>GL3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MGN:2-METHYL-GLUTAMINE'>MGN</scene>, <scene name='pdbligand=MHS:N1-METHYLATED+HISTIDINE'>MHS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SMC:S-METHYLCYSTEINE'>SMC</scene>, <scene name='pdbligand=TP7:PHOSPHORIC+ACID+N-(1-HYDROXY-7-MERCAPTO-HEPTYL)THREONINE+ESTER'>TP7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1mro| PDB=1mro | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mro OCA], [http://www.ebi.ac.uk/pdbsum/1mro PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mro RCSB]</span>
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}}
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'''METHYL-COENZYME M REDUCTASE'''
'''METHYL-COENZYME M REDUCTASE'''
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[[Category: Ermler, U.]]
[[Category: Ermler, U.]]
[[Category: Grabarse, W.]]
[[Category: Grabarse, W.]]
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[[Category: biological methanogenesis]]
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[[Category: Biological methanogenesis]]
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[[Category: ni-enzyme]]
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[[Category: Ni-enzyme]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:38:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:20:14 2008''
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Revision as of 22:38, 2 May 2008

Image:1mro.gif

Template:STRUCTURE 1mro

METHYL-COENZYME M REDUCTASE


Overview

Methyl-coenzyme M reductase (MCR), the enzyme responsible for the microbial formation of methane, is a 300-kilodalton protein organized as a hexamer in an alpha2beta2gamma2 arrangement. The crystal structure of the enzyme from Methanobacterium thermoautotrophicum, determined at 1.45 angstrom resolution for the inactive enzyme state MCRox1-silent, reveals that two molecules of the nickel porphinoid coenzyme F430 are embedded between the subunits alpha, alpha', beta, and gamma and alpha', alpha, beta', and gamma', forming two identical active sites. Each site is accessible for the substrate methyl-coenzyme M through a narrow channel locked after binding of the second substrate coenzyme B. Together with a second structurally characterized enzyme state (MCRsilent) containing the heterodisulfide of coenzymes M and B, a reaction mechanism is proposed that uses a radical intermediate and a nickel organic compound.

About this Structure

1MRO is a Protein complex structure of sequences from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation., Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK, Science. 1997 Nov 21;278(5342):1457-62. PMID:9367957 Page seeded by OCA on Sat May 3 01:38:25 2008

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OCA

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