1mry

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[[Image:1mry.gif|left|200px]]
[[Image:1mry.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mry |SIZE=350|CAPTION= <scene name='initialview01'>1mry</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1mry", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= AKT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1mry| PDB=1mry | SCENE= }}
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|RELATEDENTRY=[[1mrv|1MRV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mry OCA], [http://www.ebi.ac.uk/pdbsum/1mry PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mry RCSB]</span>
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}}
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'''crystal structure of an inactive akt2 kinase domain'''
'''crystal structure of an inactive akt2 kinase domain'''
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[[Category: Zhao, H.]]
[[Category: Zhao, H.]]
[[Category: Zhu, X.]]
[[Category: Zhu, X.]]
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[[Category: agc serine threonine kinase]]
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[[Category: Agc serine threonine kinase]]
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[[Category: akt pkb kinase domain]]
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[[Category: Akt pkb kinase domain]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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[[Category: tumorigenesis]]
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[[Category: Tumorigenesis]]
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[[Category: x-ray crystal structure]]
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[[Category: X-ray crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:38:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:20:20 2008''
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Revision as of 22:38, 2 May 2008

Image:1mry.gif

Template:STRUCTURE 1mry

crystal structure of an inactive akt2 kinase domain


Contents

Overview

Akt/PKB represents a subfamily of three isoforms from the AGC serine/threonine kinase family. Amplification of Akt activity has been implicated in diseases that involve inappropriate cell survival, including a number of human malignancies. The structure of an inactive and unliganded Akt2 kinase domain reveals several features that distinguish it from other kinases. Most of the alpha helix C is disordered. The activation loop in this structure adopts a conformation that appears to sterically hinder the binding of both ATP and peptide substrate. In addition, an intramolecular disulfide bond is observed between two cysteines in the activation loop. Residues within the linker region between the N- and C-terminal lobes also contribute to the inactive conformation by partially occupying the ATP binding site.

Disease

Known disease associated with this structure: Diabetes mellitus, type II OMIM:[164731]

About this Structure

1MRY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of an inactive Akt2 kinase domain., Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X, Structure. 2003 Jan;11(1):21-30. PMID:12517337 Page seeded by OCA on Sat May 3 01:38:57 2008

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OCA

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