3p0g

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Current revision (09:47, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3p0g' size='340' side='right'caption='[[3p0g]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='3p0g' size='340' side='right'caption='[[3p0g]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [https://en.wikipedia.org/wiki/Human Human]. The April 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3p0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. The April 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Nanobodies'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_4 10.2210/rcsb_pdb/mom_2011_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P0G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR, E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [https://pdbe.org/3p0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [https://www.ebi.ac.uk/pdbsum/3p0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p0g OCA], [https://pdbe.org/3p0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p0g RCSB], [https://www.ebi.ac.uk/pdbsum/3p0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p0g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
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[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Camelus glama]]
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[[Category: Escherichia virus T4]]
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lysozyme]]
 
[[Category: Nanobodies]]
[[Category: Nanobodies]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Casarosa, P]]
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[[Category: Casarosa P]]
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[[Category: Chae, P S]]
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[[Category: Chae PS]]
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[[Category: Choi, H J]]
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[[Category: Choi H-J]]
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[[Category: DeVree, B T]]
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[[Category: DeVree BT]]
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[[Category: Fung, J J]]
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[[Category: Fung JJ]]
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[[Category: Gellman, S H]]
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[[Category: Gellman SH]]
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[[Category: Kobilka, B K]]
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[[Category: Kobilka BK]]
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[[Category: Kobilka, T S]]
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[[Category: Kobilka TS]]
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[[Category: Konetzki, I]]
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[[Category: Konetzki I]]
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[[Category: Pardon, E]]
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[[Category: Pardon E]]
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[[Category: Pautsch, A]]
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[[Category: Pautsch A]]
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[[Category: Rasmussen, S G.F]]
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[[Category: Rasmussen SGF]]
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[[Category: Rosenbaum, D M]]
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[[Category: Rosenbaum DM]]
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[[Category: Schnapp, A]]
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[[Category: Schnapp A]]
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[[Category: Steyaert, J]]
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[[Category: Steyaert J]]
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[[Category: Sunahara, R K]]
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[[Category: Sunahara RK]]
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[[Category: Thian, F S]]
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[[Category: Thian FS]]
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[[Category: Weis, W I]]
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[[Category: Weis WI]]
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[[Category: Agonist]]
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[[Category: Beta-2 adrenoceptor]]
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[[Category: Gpcr]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Nanobody]]
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[[Category: Signaling protein]]
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Current revision

Structure of a nanobody-stabilized active state of the beta2 adrenoceptor

PDB ID 3p0g

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