3pbl

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Current revision (09:51, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3pbl' size='340' side='right'caption='[[3pbl]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
<StructureSection load='3pbl' size='340' side='right'caption='[[3pbl]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DRD3, E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [https://pdbe.org/3pbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [https://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [https://pdbe.org/3pbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [https://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Escherichia virus T4]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lysozyme]]
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[[Category: Cherezov V]]
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[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]
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[[Category: Chien EYT]]
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[[Category: Cherezov, V]]
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[[Category: Han GW]]
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[[Category: Chien, E Y.T]]
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[[Category: Katritch V]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Liu W]]
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[[Category: Han, G W]]
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[[Category: Stevens RC]]
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[[Category: Katritch, V]]
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[[Category: Zhao Q]]
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[[Category: Liu, W]]
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[[Category: Stevens, R C]]
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[[Category: Zhao, Q]]
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[[Category: Accelerated technologies center for gene to 3d structure]]
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[[Category: Atcg3d]]
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[[Category: Chimera]]
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[[Category: Dopamine]]
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[[Category: Eticlopride]]
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[[Category: G protein-coupled receptor]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Membrane protein]]
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[[Category: Neurotransmitter]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Signal transduction]]
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[[Category: Structural genomic]]
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[[Category: T4l fusion]]
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[[Category: Transmembrane]]
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Current revision

Structure of the human dopamine D3 receptor in complex with eticlopride

PDB ID 3pbl

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Proteopedia Page Contributors and Editors (what is this?)

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