3peq

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Current revision (09:52, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3peq' size='340' side='right'caption='[[3peq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3peq' size='340' side='right'caption='[[3peq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3peq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PEQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3peq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PEQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3EQ:[(4-{BUTYL[2-METHYL-4-(METHYLSULFANYL)BIPHENYL-3-YL]SULFAMOYL}NAPHTHALEN-1-YL)OXY]ACETIC+ACID'>3EQ</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1C2, PPARB, PPARD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3EQ:[(4-{BUTYL[2-METHYL-4-(METHYLSULFANYL)BIPHENYL-3-YL]SULFAMOYL}NAPHTHALEN-1-YL)OXY]ACETIC+ACID'>3EQ</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3peq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3peq OCA], [https://pdbe.org/3peq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3peq RCSB], [https://www.ebi.ac.uk/pdbsum/3peq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3peq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3peq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3peq OCA], [https://pdbe.org/3peq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3peq RCSB], [https://www.ebi.ac.uk/pdbsum/3peq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3peq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
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[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Billin, A N]]
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[[Category: Billin AN]]
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[[Category: Britt, C]]
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[[Category: Britt C]]
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[[Category: Evans, K A]]
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[[Category: Evans KA]]
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[[Category: Jin, J]]
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[[Category: Jin J]]
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[[Category: Lambert, M H]]
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[[Category: Lambert MH]]
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[[Category: Leesnitzer, L M]]
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[[Category: Leesnitzer LM]]
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[[Category: Merrihew, R V]]
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[[Category: Merrihew RV]]
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[[Category: Rivero, R A]]
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[[Category: Rivero RA]]
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[[Category: Shearer, B G]]
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[[Category: Shearer BG]]
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[[Category: Shi, D]]
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[[Category: Shi D]]
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[[Category: Sparks, S M]]
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[[Category: Sparks SM]]
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[[Category: Way, J M]]
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[[Category: Way JM]]
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[[Category: Winegar, D A]]
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[[Category: Winegar DA]]
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[[Category: Wisnoski, D D]]
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[[Category: Wisnoski DD]]
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[[Category: Ppar nuclear receptor]]
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[[Category: Transcription-transcription agonist complex]]
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Current revision

PPARd complexed with a phenoxyacetic acid partial agonist

PDB ID 3peq

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OCA

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