3pof

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Current revision (09:58, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3pof' size='340' side='right'caption='[[3pof]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='3pof' size='340' side='right'caption='[[3pof]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3POF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3POF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3POF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.501&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pob|3pob]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Crarf, MASP-1, Masp1, Masp3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [https://pdbe.org/3pof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [https://www.ebi.ac.uk/pdbsum/3pof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pof ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pof OCA], [https://pdbe.org/3pof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pof RCSB], [https://www.ebi.ac.uk/pdbsum/3pof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pof ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MASP1_RAT MASP1_RAT]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5 (By similarity).
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[https://www.uniprot.org/uniprot/MASP1_RAT MASP1_RAT] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5 (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gingras, A R]]
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[[Category: Rattus norvegicus]]
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[[Category: Moody, P C.E]]
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[[Category: Gingras AR]]
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[[Category: Wallis, R]]
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[[Category: Moody PCE]]
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[[Category: Bloodstream]]
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[[Category: Wallis R]]
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[[Category: Ca2+ binding site]]
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[[Category: Complement protein]]
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[[Category: Cub domain]]
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[[Category: Ficolin]]
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[[Category: Hydrolase]]
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[[Category: Lectin pathway of complement]]
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[[Category: Mbl]]
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[[Category: Mbp]]
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Current revision

Crystal structure of MASP-1 CUB2 domain bound to Ca2+

PDB ID 3pof

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