7lbc
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Structure of human GGT1 in complex with Lnt2-65 compound== |
| - | <StructureSection load='7lbc' size='340' side='right'caption='[[7lbc]]' scene=''> | + | <StructureSection load='7lbc' size='340' side='right'caption='[[7lbc]], [[Resolution|resolution]] 2.28Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7lbc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LBC FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lbc OCA], [https://pdbe.org/7lbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lbc RCSB], [https://www.ebi.ac.uk/pdbsum/7lbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lbc ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XSA:(2R)-2-[(2-aminoethyl)amino]-4-boronobutanoic+acid'>XSA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lbc OCA], [https://pdbe.org/7lbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lbc RCSB], [https://www.ebi.ac.uk/pdbsum/7lbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lbc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN] Gamma-glutamyl transpeptidase deficiency. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GGT1_HUMAN GGT1_HUMAN] Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.<ref>PMID:7689219</ref> <ref>PMID:20622017</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Hanigan M]] |
| + | [[Category: Terzyan SS]] | ||
Revision as of 10:06, 6 September 2023
Structure of human GGT1 in complex with Lnt2-65 compound
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