7u4t

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==Human V-ATPase in state 2 with SidK and mEAK-7==
==Human V-ATPase in state 2 with SidK and mEAK-7==
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<StructureSection load='7u4t' size='340' side='right'caption='[[7u4t]]' scene=''>
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<StructureSection load='7u4t' size='340' side='right'caption='[[7u4t]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7u4t]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4T FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4t OCA], [https://pdbe.org/7u4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4t RCSB], [https://www.ebi.ac.uk/pdbsum/7u4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4t ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4t OCA], [https://pdbe.org/7u4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4t RCSB], [https://www.ebi.ac.uk/pdbsum/7u4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4t ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VPP1_HUMAN VPP1_HUMAN] The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/VPP1_HUMAN VPP1_HUMAN] Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles (PubMed:33065002, PubMed:34909687, PubMed:33833240). In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (PubMed:33833240).[UniProtKB:P32563][UniProtKB:Q29466]<ref>PMID:33065002</ref> <ref>PMID:33833240</ref> <ref>PMID:34909687</ref>
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==See Also==
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*[[ATPase 3D structures|ATPase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fu TM]]
[[Category: Fu TM]]
[[Category: Wang L]]
[[Category: Wang L]]

Revision as of 10:07, 6 September 2023

Human V-ATPase in state 2 with SidK and mEAK-7

PDB ID 7u4t

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