5iuq

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Current revision (10:32, 6 September 2023) (edit) (undo)
 
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==Galectin-3c in complex with Bisamido-thiogalactoside derivative 4==
==Galectin-3c in complex with Bisamido-thiogalactoside derivative 4==
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<StructureSection load='5iuq' size='340' side='right' caption='[[5iuq]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
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<StructureSection load='5iuq' size='340' side='right'caption='[[5iuq]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5iuq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5iuq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IUQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6E1:3-DEOXY-3-[(2,3,5,6-TETRAFLUORO-4-METHOXYBENZENE-1-CARBONYL)AMINO]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[(2,3,5,6-TETRAFLUORO-4-METHOXYBENZENE-1-CARBONYL)AMINO]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>6E1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.121&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4blj|4blj]], [[4bli|4bli]], [[4bm8|4bm8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6E1:3-DEOXY-3-[(2,3,5,6-TETRAFLUORO-4-METHOXYBENZENE-1-CARBONYL)AMINO]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[(2,3,5,6-TETRAFLUORO-4-METHOXYBENZENE-1-CARBONYL)AMINO]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>6E1</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LGALS3, MAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iuq OCA], [https://pdbe.org/5iuq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iuq RCSB], [https://www.ebi.ac.uk/pdbsum/5iuq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iuq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iuq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iuq OCA], [http://pdbe.org/5iuq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iuq RCSB], [http://www.ebi.ac.uk/pdbsum/5iuq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iuq ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
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[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
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==See Also==
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*[[Galectin 3D structures|Galectin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Aurelius, O]]
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[[Category: Large Structures]]
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[[Category: Engstrom, O]]
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[[Category: Aurelius O]]
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[[Category: Hakansson, M]]
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[[Category: Engstrom O]]
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[[Category: Leffler, H]]
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[[Category: Hakansson M]]
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[[Category: Logan, D T]]
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[[Category: Leffler H]]
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[[Category: Nilsson, U J]]
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[[Category: Logan DT]]
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[[Category: Noresson, A L]]
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[[Category: Nilsson UJ]]
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[[Category: Oberg, C T]]
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[[Category: Noresson A-L]]
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[[Category: Sundin, A P]]
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[[Category: Oberg CT]]
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[[Category: Crd]]
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[[Category: Sundin AP]]
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[[Category: Gal3c]]
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[[Category: Sugar binding protein]]
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Current revision

Galectin-3c in complex with Bisamido-thiogalactoside derivative 4

PDB ID 5iuq

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