1mt6

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[[Image:1mt6.jpg|left|200px]]
[[Image:1mt6.jpg|left|200px]]
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{{Structure
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|PDB= 1mt6 |SIZE=350|CAPTION= <scene name='initialview01'>1mt6</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1mt6", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span>
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{{STRUCTURE_1mt6| PDB=1mt6 | SCENE= }}
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|RELATEDENTRY=[[1muf|1MUF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mt6 OCA], [http://www.ebi.ac.uk/pdbsum/1mt6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mt6 RCSB]</span>
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'''Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy'''
'''Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy'''
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[[Category: Kim, Y.]]
[[Category: Kim, Y.]]
[[Category: Rastinejad, F.]]
[[Category: Rastinejad, F.]]
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[[Category: adohcy]]
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[[Category: Adohcy]]
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[[Category: histone lysine methyltransferase]]
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[[Category: Histone lysine methyltransferase]]
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[[Category: knot]]
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[[Category: Knot]]
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[[Category: set domain]]
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[[Category: Set domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:41:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:20:47 2008''
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Revision as of 22:41, 2 May 2008

Image:1mt6.jpg

Template:STRUCTURE 1mt6

Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy


Overview

The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.

About this Structure

1MT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The active site of the SET domain is constructed on a knot., Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S, Nat Struct Biol. 2002 Nov;9(11):833-8. PMID:12389038 Page seeded by OCA on Sat May 3 01:41:24 2008

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