5j63
From Proteopedia
(Difference between revisions)
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<StructureSection load='5j63' size='340' side='right'caption='[[5j63]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='5j63' size='340' side='right'caption='[[5j63]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5j63]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5j63]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_H736 Escherichia coli H736]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J63 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FNX:(4AS,6S)-2-AMINO-6-{(E)-[(4-METHYLPHENYL)IMINO]METHYL}-4-OXO-4,6,7,8-TETRAHYDROPTERIDINE-5(4AH)-CARBALDEHYDE'>FNX</scene>, <scene name='pdbligand=G3N:(2R,3R,4S,5S)-5-AMINO-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL+[(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>G3N</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FNX:(4AS,6S)-2-AMINO-6-{(E)-[(4-METHYLPHENYL)IMINO]METHYL}-4-OXO-4,6,7,8-TETRAHYDROPTERIDINE-5(4AH)-CARBALDEHYDE'>FNX</scene>, <scene name='pdbligand=G3N:(2R,3R,4S,5S)-5-AMINO-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL+[(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>G3N</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j63 OCA], [https://pdbe.org/5j63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j63 RCSB], [https://www.ebi.ac.uk/pdbsum/5j63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j63 ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/F4SGI5_ECOLX F4SGI5_ECOLX]] Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.[HAMAP-Rule:MF_01166][SAAS:SAAS00331614] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Escherichia coli | + | [[Category: Escherichia coli H736]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Genthe | + | [[Category: Genthe NA]] |
| - | [[Category: Holden | + | [[Category: Holden HM]] |
| - | [[Category: Thoden | + | [[Category: Thoden JB]] |
| - | + | ||
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Current revision
Crystal Structure of the N-terminal N-formyltransferase Domain (residues 1-306) of Escherichia coli Arna in Complex with UDP-Ara4N and Folinic Acid
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