5jct

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Current revision (10:59, 6 September 2023) (edit) (undo)
 
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<StructureSection load='5jct' size='340' side='right'caption='[[5jct]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
<StructureSection load='5jct' size='340' side='right'caption='[[5jct]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JCT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JCT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JCT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6JQ:N-{5-[(2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBONYL)AMINO]-2-METHYLPHENYL}-2-[3-(PYRROLIDIN-1-YL)PROPYL]QUINOLINE-6-CARBOXAMIDE'>6JQ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6JQ:N-{5-[(2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBONYL)AMINO]-2-METHYLPHENYL}-2-[3-(PYRROLIDIN-1-YL)PROPYL]QUINOLINE-6-CARBOXAMIDE'>6JQ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Quercetin_2,3-dioxygenase Quercetin 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.24 1.13.11.24] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jct OCA], [https://pdbe.org/5jct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jct RCSB], [https://www.ebi.ac.uk/pdbsum/5jct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jct ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jct OCA], [http://pdbe.org/5jct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jct RCSB], [http://www.ebi.ac.uk/pdbsum/5jct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jct ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN]] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref>
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[https://www.uniprot.org/uniprot/PIR_HUMAN PIR_HUMAN] Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).<ref>PMID:9079676</ref> <ref>PMID:17288615</ref> <ref>PMID:20010624</ref> <ref>PMID:20711196</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jct" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jct" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Quercetin 2,3-dioxygenase]]
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[[Category: Ali S]]
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[[Category: Ali, S]]
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[[Category: Van Montfort R]]
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[[Category: Montfort, R van]]
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[[Category: Beta-barrel fold]]
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[[Category: Complex]]
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[[Category: Cupin]]
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[[Category: Inhibitor]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal Structure of Human Pirin in complex with a Chemical Probe pyrrolidine 24

PDB ID 5jct

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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