Preprotein translocase

Function

Preprotein translocase (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor^[1]. The translocase pathway contains:

• SecB - a chaperone protein^[2]
  
• SecY, SecE, SecG or Sec61 an integral membrane complex
  
• SecD, SecF - proteins promoting the release of the mature peptide into the periplasm
  
• SecA - an ATPase unit^[3].
  

For more details see SecA PBD motions.

3D structures of preprotein translocase

Preprotein translocase 3D structures

Updated on 12-September-2023

References

1. ↑ Economou A. Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme. Mol Microbiol. 1998 Feb;27(3):511-8. PMID:9489663
2. ↑ Fekkes P, de Wit JG, van der Wolk JP, Kimsey HH, Kumamoto CA, Driessen AJ. Preprotein transfer to the Escherichia coli translocase requires the co-operative binding of SecB and the signal sequence to SecA. Mol Microbiol. 1998 Sep;29(5):1179-90. PMID:9767586
3. ↑ Schmidt MG, Kiser KB. SecA: the ubiquitous component of preprotein translocase in prokaryotes. Microbes Infect. 1999 Oct;1(12):993-1004. PMID:10617931