1muy

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[[Image:1muy.gif|left|200px]]
[[Image:1muy.gif|left|200px]]
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{{Structure
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|PDB= 1muy |SIZE=350|CAPTION= <scene name='initialview01'>1muy</scene>, resolution 1.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1muy", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>
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{{STRUCTURE_1muy| PDB=1muy | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1muy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1muy OCA], [http://www.ebi.ac.uk/pdbsum/1muy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1muy RCSB]</span>
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'''CATALYTIC DOMAIN OF MUTY FROM ESCHERICHIA COLI'''
'''CATALYTIC DOMAIN OF MUTY FROM ESCHERICHIA COLI'''
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[[Category: Guan, Y.]]
[[Category: Guan, Y.]]
[[Category: Tainer, J A.]]
[[Category: Tainer, J A.]]
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[[Category: dna g a mismatch repair enzyme]]
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[[Category: Dna g a mismatch repair enzyme]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: glycosidase]]
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[[Category: Glycosidase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:45:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:27 2008''
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Revision as of 22:45, 2 May 2008

Image:1muy.gif

Template:STRUCTURE 1muy

CATALYTIC DOMAIN OF MUTY FROM ESCHERICHIA COLI


Overview

The DNA glycosylase MutY, which is a member of the Helix-hairpin-Helix (HhH) DNA glycosylase superfamily, excises adenine from mispairs with 8-oxoguanine and guanine. High-resolution crystal structures of the MutY catalytic core (cMutY), the complex with bound adenine, and designed mutants reveal the basis for adenine specificity and glycosyl bond cleavage chemistry. The two cMutY helical domains form a positively-charged groove with the adenine-specific pocket at their interface. The Watson-Crick hydrogen bond partners of the bound adenine are substituted by protein atoms, confirming a nucleotide flipping mechanism, and supporting a specific DNA binding orientation by MutY and structurally related DNA glycosylases.

About this Structure

1MUY is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily., Guan Y, Manuel RC, Arvai AS, Parikh SS, Mol CD, Miller JH, Lloyd S, Tainer JA, Nat Struct Biol. 1998 Dec;5(12):1058-64. PMID:9846876 Page seeded by OCA on Sat May 3 01:45:11 2008

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