1mwe

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1mwe.gif|left|200px]]
[[Image:1mwe.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1mwe |SIZE=350|CAPTION= <scene name='initialview01'>1mwe</scene>, resolution 1.7&Aring;
+
The line below this paragraph, containing "STRUCTURE_1mwe", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1mwe| PDB=1mwe | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mwe OCA], [http://www.ebi.ac.uk/pdbsum/1mwe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mwe RCSB]</span>
+
-
}}
+
'''THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH SIALIC ACID AT 4 DEGREES C REVEALING A SECOND SIALIC ACID BINDING SITE'''
'''THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH SIALIC ACID AT 4 DEGREES C REVEALING A SECOND SIALIC ACID BINDING SITE'''
Line 27: Line 24:
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Varghese, J N.]]
[[Category: Varghese, J N.]]
-
[[Category: avian influenza]]
+
[[Category: Avian influenza]]
-
[[Category: hemagglutination site]]
+
[[Category: Hemagglutination site]]
-
[[Category: heme absorbing site]]
+
[[Category: Heme absorbing site]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: neuraminidase]]
+
[[Category: Neuraminidase]]
-
[[Category: sialic acid binding]]
+
[[Category: Sialic acid binding]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:48:04 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:22:03 2008''
+

Revision as of 22:48, 2 May 2008

Image:1mwe.gif

Template:STRUCTURE 1mwe

THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH SIALIC ACID AT 4 DEGREES C REVEALING A SECOND SIALIC ACID BINDING SITE


Overview

The x-ray structure of a complex of sialic acid (Neu5Ac) with neuraminidase N9 subtype from A/tern/Australia/G70C/75 influenza virus at 4 degrees C has revealed the location of a second Neu5Ac binding site on the surface of the enzyme. At 18 degrees C, only the enzyme active site contains bound Neu5Ac. Neu5Ac binds in the second site in the chair conformation in a similar way to which it binds to hemagglutinin. The residues that interact with Neu5Ac at this second site are mostly conserved in avian strains, but not in human and swine strains, indicating that it has some as-yet-unknown biological function in birds.

About this Structure

1MWE is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases., Varghese JN, Colman PM, van Donkelaar A, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL, Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11808-12. PMID:9342319 Page seeded by OCA on Sat May 3 01:48:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mwe"
Personal tools