1n83
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(New page: 200px<br /> <applet load="1n83" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n83, resolution 1.63Å" /> '''Crystal Structure o...)
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Revision as of 16:12, 12 November 2007
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Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol
Overview
The retinoic acid-related orphan receptor alpha (RORalpha) is an orphan, member of the subfamily 1 of nuclear hormone receptors. No X-ray structure, of RORalpha has been described so far, and no ligand has been identified., We describe the first crystal structure of the ligand binding domain (LBD), of RORalpha, at 1.63 A resolution. This structure revealed a ligand, present in the ligand binding pocket (LBP), which was identified by X-ray, crystallography as cholest-5-en-3beta-ol (cholesterol). Moreover, RORalpha, transcriptional activity could be modulated by changes in intracellular, cholesterol level or mutation of residues involved in cholesterol binding., These findings suggest that RORalpha could play a key role in the, regulation of cholesterol homeostasis and thus represents an important, drug target in cholesterol-related diseases.
About this Structure
1N83 is a Single protein structure of sequence from Homo sapiens with CLR as ligand. Full crystallographic information is available from OCA.
Reference
X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha., Kallen JA, Schlaeppi JM, Bitsch F, Geisse S, Geiser M, Delhon I, Fournier B, Structure. 2002 Dec;10(12):1697-707. PMID:12467577
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