1mx3

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[[Image:1mx3.gif|left|200px]]
[[Image:1mx3.gif|left|200px]]
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{{Structure
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|PDB= 1mx3 |SIZE=350|CAPTION= <scene name='initialview01'>1mx3</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1mx3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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|ACTIVITY=
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|GENE= CTBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1mx3| PDB=1mx3 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mx3 OCA], [http://www.ebi.ac.uk/pdbsum/1mx3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mx3 RCSB]</span>
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'''Crystal structure of CtBP dehydrogenase core holo form'''
'''Crystal structure of CtBP dehydrogenase core holo form'''
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[[Category: Ohgi, K E.]]
[[Category: Ohgi, K E.]]
[[Category: Rose, D W.]]
[[Category: Rose, D W.]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: transcriptional corepressor]]
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[[Category: Transcriptional corepressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:49:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:22:19 2008''
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Revision as of 22:49, 2 May 2008

Image:1mx3.gif

Template:STRUCTURE 1mx3

Crystal structure of CtBP dehydrogenase core holo form


Overview

Transcriptional repression is based on the selective actions of recruited corepressor complexes, including those with enzymatic activities. One well-characterized developmentally important corepressor is the C-terminal binding protein (CtBP). Although intriguingly related in sequence to D2 hydroxyacid dehydrogenases, the mechanism by which CtBP functions remains unclear. We report here biochemical and crystallographic studies which reveal that CtBP is a functional dehydrogenase. In addition, both a cofactor-dependent conformational change, with NAD(+) and NADH being equivalently effective, and the active site residues are linked to the binding of the PXDLS consensus recognition motif on repressors, such as E1A and RIP140. Together, our data suggest that CtBP is an NAD(+)-regulated component of critical complexes for specific repression events in cells.

About this Structure

1MX3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase., Kumar V, Carlson JE, Ohgi KA, Edwards TA, Rose DW, Escalante CR, Rosenfeld MG, Aggarwal AK, Mol Cell. 2002 Oct;10(4):857-69. PMID:12419229 Page seeded by OCA on Sat May 3 01:49:31 2008

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