1mxs

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[[Image:1mxs.gif|left|200px]]
[[Image:1mxs.gif|left|200px]]
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{{Structure
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|PDB= 1mxs |SIZE=350|CAPTION= <scene name='initialview01'>1mxs</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1mxs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/2-dehydro-3-deoxy-phosphogluconate_aldolase 2-dehydro-3-deoxy-phosphogluconate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.14 4.1.2.14] </span>
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{{STRUCTURE_1mxs| PDB=1mxs | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mxs OCA], [http://www.ebi.ac.uk/pdbsum/1mxs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mxs RCSB]</span>
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'''Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Pseudomonas putida.'''
'''Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Pseudomonas putida.'''
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[[Category: Watanabe, L.]]
[[Category: Watanabe, L.]]
[[Category: 2-keto-3-deoxy-6-phosphogluconate aldolase]]
[[Category: 2-keto-3-deoxy-6-phosphogluconate aldolase]]
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[[Category: beta-barrel]]
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[[Category: Beta-barrel]]
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[[Category: sulfate]]
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[[Category: Sulfate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:50:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:22:40 2008''
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Revision as of 22:50, 2 May 2008

Image:1mxs.gif

Template:STRUCTURE 1mxs

Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Pseudomonas putida.


Overview

2-Keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Pseudomonas putida is a key enzyme in the Entner-Doudoroff pathway which catalyses the cleavage of KDPG via a class I Schiff-base mechanism. The crystal structure of this enzyme has been refined to a crystallographic residual R = 17.1% (R(free) = 21.4%). The N-terminal helix caps one side of the torus of the (betaalpha)(8)-barrel and the active site is located on the opposite, carboxylic side of the barrel. The Schiff-base-forming Lys145 is coordinated by a sulfate (or phosphate) ion and two solvent water molecules. The interactions that stabilize the trimer are predominantly hydrophobic, with the exception of the cyclically permuted bonds formed between Glu132 OE1 of one molecule and Thr129 OG1 of a symmetry-equivalent molecule. Except for the N-terminal helix, the structure of KDPG aldolase from P. putida closely resembles the structure of the homologous enzyme from Escherichia coli.

About this Structure

1MXS is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Structure of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Pseudomonas putida., Bell BJ, Watanabe L, Rios-Steiner JL, Tulinsky A, Lebioda L, Arni RK, Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1454-8. Epub 2003, Jul 23. PMID:12876349 Page seeded by OCA on Sat May 3 01:50:57 2008

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