1myu
From Proteopedia
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[[Image:1myu.gif|left|200px]] | [[Image:1myu.gif|left|200px]] | ||
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'''Lipid induced conformation of the tachykinin peptide Kassinin''' | '''Lipid induced conformation of the tachykinin peptide Kassinin''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MYU is a [[Single protein]] structure | + | 1MYU is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Lynn, A M.]] | [[Category: Lynn, A M.]] | ||
[[Category: 3-10 helix]] | [[Category: 3-10 helix]] | ||
| - | [[Category: | + | [[Category: Dpc micelle]] |
| - | [[Category: | + | [[Category: Helical core]] |
| - | [[Category: | + | [[Category: Lipid induced conformation]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:52:49 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 22:52, 2 May 2008
Lipid induced conformation of the tachykinin peptide Kassinin
Overview
Both the aqueous and lipid-induced structure of Kassinin, a dodecapeptide of amphibian origin, has been studied by two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy and distance geometry calculations. Unambiguous NMR assignments of protons have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and nuclear Overhauser effect spectroscopy (NOESY and ROESY) experiments. The distance constraints obtained from the NMR data have been utilized in a distance geometry algorithm to generate a family of structures, which have been refined using restrained energy minimization and dynamics. These data show that, while in water Kassinin prefers to be in an extended chain conformation, in the presence of perdeuterated dodecylphosphocholine (DPC) micelles, a membrane model system, helical conformation is induced in the central core and C-terminal region (K4-M12) of the peptide. N-terminus though less defined also displays some degree of order and a possible turn structure. The conformation adopted by Kassinin in the presence of DPC micelles is consistent with the structural motif typical of neurokinin-1 selective agonists and with that reported for Eledoisin in hydrophobic environment.
About this Structure
1MYU is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Lipid induced conformation of the tachykinin peptide Kassinin., Grace RC, Lynn AM, Cowsik SM, J Biomol Struct Dyn. 2001 Feb;18(4):611-21, 623-5. PMID:11245256 Page seeded by OCA on Sat May 3 01:52:49 2008
