1mzj

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[[Image:1mzj.jpg|left|200px]]
[[Image:1mzj.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1mzj |SIZE=350|CAPTION= <scene name='initialview01'>1mzj</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1mzj", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= zhuH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=140437 Streptomyces sp. R1128])
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|DOMAIN=
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{{STRUCTURE_1mzj| PDB=1mzj | SCENE= }}
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|RELATEDENTRY=[[1ebl|1EBL]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mzj OCA], [http://www.ebi.ac.uk/pdbsum/1mzj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mzj RCSB]</span>
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}}
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'''Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway'''
'''Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway'''
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[[Category: Stroud, R M.]]
[[Category: Stroud, R M.]]
[[Category: Tsai, S C.]]
[[Category: Tsai, S C.]]
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[[Category: aromatic polyketide]]
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[[Category: Aromatic polyketide]]
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[[Category: beta-ketosynthase]]
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[[Category: Beta-ketosynthase]]
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[[Category: biosynthetic engineering]]
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[[Category: Biosynthetic engineering]]
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[[Category: catalytic triad]]
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[[Category: Catalytic triad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:54:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:23:16 2008''
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Revision as of 22:54, 2 May 2008

Image:1mzj.jpg

Template:STRUCTURE 1mzj

Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway


Overview

ZhuH is a priming ketosynthase that initiates the elongation of the polyketide chain in the biosynthetic pathway of a type II polyketide, R1128. The crystal structure of ZhuH in complex with the priming substrate acetyl-CoA reveals an extensive loop region at the dimer interface that appears to affect the selectivity for the primer unit. Acetyl-CoA is bound in a 20 A-long channel, which placed the acetyl group against the catalytic triad. Analysis of the primer unit binding site in ZhuH suggests that it can accommodate acyl chains that are two to four carbons long. Selectivity and primer unit size appear to involve the side chains of three residues on the loops close to the dimer interface that constitute the bottom of the substrate binding pocket.

About this Structure

1MZJ is a Single protein structure of sequence from Streptomyces sp. r1128. Full crystallographic information is available from OCA.

Reference

Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway., Pan H, Tsai S, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM, Structure. 2002 Nov;10(11):1559-68. PMID:12429097 Page seeded by OCA on Sat May 3 01:54:00 2008

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