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5jkr

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Current revision (18:57, 20 September 2023) (edit) (undo)
 
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<StructureSection load='5jkr' size='340' side='right'caption='[[5jkr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5jkr' size='340' side='right'caption='[[5jkr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jkr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccc Vaccc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JKR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JKR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jkr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Copenhagen Vaccinia virus Copenhagen]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JKR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UNG, D4R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10249 VACCC]), A20R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10249 VACCC])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jkr OCA], [https://pdbe.org/5jkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jkr RCSB], [https://www.ebi.ac.uk/pdbsum/5jkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jkr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jkr OCA], [http://pdbe.org/5jkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jkr RCSB], [http://www.ebi.ac.uk/pdbsum/5jkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jkr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UNG_VACCC UNG_VACCC]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA (By similarity). [[http://www.uniprot.org/uniprot/A20_VACCC A20_VACCC]] Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein D4. May serve as a bridge which links the DNA polymerase E9 and the uracil DNA glycosylase (By similarity).
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[https://www.uniprot.org/uniprot/UNG_VACCC UNG_VACCC] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Uracil-DNA glycosylase]]
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[[Category: Vaccinia virus Copenhagen]]
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[[Category: Vaccc]]
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[[Category: Brazzolotto X]]
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[[Category: Brazzolotto, X]]
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[[Category: Burmeister WP]]
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[[Category: Burmeister, W P]]
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[[Category: Contesto-Richefeu C]]
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[[Category: Contesto-Richefeu, C]]
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[[Category: Iseni F]]
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[[Category: Iseni, F]]
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[[Category: Peyrefitte CN]]
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[[Category: Peyrefitte, C N]]
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[[Category: Tarbouriech N]]
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[[Category: Tarbouriech, N]]
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[[Category: Dna binding]]
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[[Category: Dna polymerase binding]]
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[[Category: Dna polymerase processivity factor]]
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[[Category: Hydrolase-replication complex]]
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Current revision

vaccinia virus D4/A20(1-50)w43a mutant

PDB ID 5jkr

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OCA

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